Team 14 from Artesia High School is comprised of Kathryn Moore, senior, and Jessica MacKinnon, junior. The project focused on the Biochemistry and Genetics of Duchenne Muscular Dystrophy. Duchenne Muscular Dystrophy, an x-linked recessive disease also known as DMD, targets young males. James Moore, Kathryn Moore's younger brother, inherited this disease from his mother, Sondra. Kathryn does not have Duchenne Muscular Dystrophy because she is female, and therefore she inherited two x chromosomes. The second x chromosome protects the female from the disease because it, in essence, "replaces" the defective DNA in the first chromosome. The DMD defective chromosome is shown below:
The time it takes to search through each individual base pair for Duchenne-causing mutations in the DNA drastically increases the time needed to find a potential treatment for DMD. To erase the need for this tedious step, Team 14 created a Java algorithm to find the mutations in the DNA and "print" out the mutated gene sequences in order of occurrence. |